Incidence and clinical characteristics of clonal cytogenetic abnormalities of acquired aplastic anemia in adults
Korean Journal of Hematology
;
: 242-246, 2010.
Article
in English
| WPRIM
| ID: wpr-720659
ABSTRACT
BACKGROUND:
Cytogenetic abnormalities (CAs) have been reported frequently in patients with otherwise typical aplastic anemia (AA), but their implications in the prognosis and in the evolution to hematologic malignancies are controversial.METHODS:
We retrospectively analyzed 127 adult AA patients who had successful cytogenetic analysis at initial diagnosis.RESULTS:
The patients were classified into 3 groups according to the initial and follow-up results of cytogenetic profiles. Group 1 included patients who had persistent AA with normal cytogenetic profiles (N=117); Group 2, those who had a normal cytogenetic profile at initial diagnosis but later acquired CA (N=4, 3.1%); and Group 3, those who had CA at the initial diagnosis, regardless of follow-up cytogenetic status (N=6,4.7%). In Group 2, 2 patients later developed CA without progression to acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS); the other 2 patients later progressed to AML. None of the patients in Group 3 progressed to AML or MDS. There was no significant difference in overall survival between Groups 1 and 3.CONCLUSION:
AA patients with CA at initial diagnosis or follow-up may not be at greater risk for evolution to AML or MDS, or show shorter survival periods. Prospective studies and a larger patient samples are needed to establish the clinical relevance of CA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Myelodysplastic Syndromes
/
Leukemia, Myeloid, Acute
/
Incidence
/
Retrospective Studies
/
Follow-Up Studies
/
Chromosome Aberrations
/
Hematologic Neoplasms
/
Cytogenetic Analysis
/
Cytogenetics
Type of study:
Incidence study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Korean Journal of Hematology
Year:
2010
Type:
Article
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