Knockdown of 14-3-3zeta enhances radiosensitivity and radio-induced apoptosis in CD133+ liver cancer stem cells
Experimental & Molecular Medicine
; : e77-2014.
Article
in En
| WPRIM
| ID: wpr-72396
Responsible library:
WPRO
ABSTRACT
14-3-3zeta is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3zeta decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study, we investigated whether silencing 14-3-3zeta affects the radioresistance of cancer stem-like cells (CSCs) in HCC. Knockdown of 14-3-3zeta decreased cell viability and the number of spheres by reducing radioresistance in CSCs after gamma-irradiation (IR). Furthermore, the levels of pro-apoptotic proteins were upregulated in CSCs via silencing 14-3-3zeta after IR. These results suggest that 14-3-3zeta knockdown enhances radio-induced apoptosis by reducing radioresistance in liver CSCs.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Peptides
/
Radiation Tolerance
/
Neoplastic Stem Cells
/
Glycoproteins
/
Antigens, CD
/
Carcinoma, Hepatocellular
/
Cell Line, Tumor
/
14-3-3 Proteins
/
Apoptosis Regulatory Proteins
/
Gamma Rays
Limits:
Humans
Language:
En
Journal:
Experimental & Molecular Medicine
Year:
2014
Type:
Article