Comparative Study on Initial Symptoms Using Single Photon Emission Computer Tomography in Schizophrenia
Journal of the Korean Society of Biological Psychiatry
; : 127-135, 2010.
Article
in Ko
| WPRIM
| ID: wpr-725301
Responsible library:
WPRO
ABSTRACT
OBJECTIVES: This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain (99m)Tc-ECD SPECT. METHODS: Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent (99m)Tc-ECD SPECT. RESULTS: Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe. CONCLUSION: The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Parietal Lobe
/
Perfusion
/
Schizophrenia
/
Temporal Lobe
/
Thinking
/
Brain
/
Tomography, Emission-Computed, Single-Photon
/
Delusions
/
Frontal Lobe
/
Hallucinations
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
Ko
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2010
Type:
Article