Spontaneous Contractions Augmented by Cholinergic and Adrenergic Systems in the Human Ureter
The Korean Journal of Physiology and Pharmacology
; : 37-41, 2011.
Article
in En
| WPRIM
| ID: wpr-727379
Responsible library:
WPRO
ABSTRACT
Interstitial cells of Cajal (ICC) evoke pacemaker activities in many tissues. The purpose of this study was to investigate the relationship between interstitial cell and pacemaker activity in the human ureter through the recording of spontaneous contractions. Spontaneous contractions of eight circular and longitudinal smooth muscle strips of the human ureter to acetylcholine (ACh) and/or norepinephrine (NE) were observed. Human ureteral strips were divided into proximal and distal groups, and each group was subdivided into circular and longitudinal groups. The proximal group showed spontaneous activities of 3~4 times within 5 minutes in the longitudinal group. ACh (10(-4) M) augmented the frequency of the spontaneous contractions. The cumulative application of NE also augmented the frequency in a dose-dependent manner. The effects of NE application were inhibited by concomitant application of 10(-5) M glibenclamide. Receptor tyrosine kinase (c-kit) staining revealed abundant ICCs only in proximal tissues. Therefore, spontaneous contractions of the human ureter might be modulated by ICC in the proximal region, and the actions might be related with the activation of cholinergic and/or adrenergic system mediated by a glibenclamide-sensitive pathway.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Ureter
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Protein-Tyrosine Kinases
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Acetylcholine
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Norepinephrine
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Glyburide
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Contracts
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Interstitial Cells of Cajal
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Muscle, Smooth
Limits:
Humans
Language:
En
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2011
Type:
Article