Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
The Korean Journal of Physiology and Pharmacology
; : 113-119, 2007.
Article
in En
| WPRIM
| ID: wpr-728479
Responsible library:
WPRO
ABSTRACT
Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a 5-HT1A receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated groups. The LPS-treated group showed impaired motor coordination in the Rota-rod test. The LPS- treated or both LPS and NAN-190-treated groups showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is a promising strategy of establishing an animal model for developmental disabilities.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Serotonin
/
Developmental Disabilities
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Rats, Sprague-Dawley
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Tilt-Table Test
/
Models, Animal
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Receptor, Serotonin, 5-HT1A
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Inflammation
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Neurologic Manifestations
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2007
Type:
Article