Research progress of intestinal flora imbalance in children with nonalcoholic fatty liver disease / 国际儿科学杂志

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in children.Compared with adults,NAFLD in children progresses rapidly and the prognosis is poor.A number of studies have demonstrated that intestinal flora imbalance plays an important role in the pathogenesis of NAFLD.The development of microbes in the intestinal can be traced back to the intrauterine period,and the diversity of microbes mainly occurs in childhood.At present,the exploration of drug therapy for children with NAFLD is still underway.Adjusting the intestinal flora can improve the state of oxidative stress and inflammatory injury in the liver,so as to improve the body's metabolic abnormality and delay the progression of liver disease in NAFLD patients,which has important clinical significance in preventing and treating NAFLD in children.