Risk factors of intrahepatic recurrence after resection for Barcelona Clinic Liver Cancer stage 0 hepatocellular carcinoma / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 793-796, 2018.
Article
in Zh
| WPRIM
| ID: wpr-734378
Responsible library:
WPRO
ABSTRACT
Objective To investigate the risk factors of intrahepatic recurrence after resection for Barcelona Clinic Liver Cancer (BCLC) stage 0 hepatocellular carcinoma (HCC).Methods 58 patients with pathologically confirmed BCLC stage 0 HCC treated with liver resection at the Zhongshan Hospital,Fudan University from January to December 2011 were included in this study.The male/female ratio was 50/8.The age ranged from 31 to 72 years.The clinical,pathological and MR imaging features of these patients were analyzed.The recurrence-free survival rates between patients with HCC ≤ 1.5 cm (n=27) and > 1.5 cm (n=31) were compared.The risk factors of intrahepatic recurrence for HCCs were compared using the Cox regression analysis.Results Intrahepatic recurrence was identified in 25 patients,and the median recurrence time was 33 months.The 3-and 5-year cumulative recurrence-free survival rates were 73.0% (95%CI60.7%~85.3%) and 52.3% (95%CI37.2%~67.4%).No significant differences were found in the recurrence-free survival rates between tumors ≤ 1.5 cm and > 1.5 cm (P>0.05).Multivariate analyses demonstrated that serum alpha-fetoprotein level >20 g/L (HR 3.773,95%CI1.628~8.745;P<0.05) and irregular tumor shape (HR 4.584,95%CI1.485~ 14.155;P<0.05) were independent risk factors of intrahepatic recurrence.Conclusions Elevated serum alpha-fetoprotein level and irregular tumor shape were associated with an increased risk of intrahepatic recurrence for BCLC stage 0 HCC patients after resection.They could be used as early prognostic indicators in clinical practice.
Full text:
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Index:
WPRIM
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Hepatobiliary Surgery
Year:
2018
Type:
Article