Study on serum PDGF-BB as biomarker for diabetic retinopathy / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM:To observe the correlation between serum level of platelet derived growth factor -BB(PDGF-BB)and diabetic retinopathy(DR)in type 2 diabetic patients.<p>METHODS: Seventy-five cases of healthy subjects underwent physical examination were taken as control group. Diabetic patients were divided into non-diabetic retinopathy group(NDR, 25 cases), non-proliferative diabetic retinopathy group(NPDR, 25 cases)and proliferative diabetic retinopathy group(PDR, 25 cases). Serum level of each group was measured using Enzyme-Linked Immunosorbent Assay(ELISA). Correlation between serum PDGF-BB level and stages of diabetes mellitus, macular thickness, glycosylated hemoglobin, and other biochemical indexes in serum were analyzed. <p>RESULTS: Serum level of PDGF-BB in control group(400.28±44.55pg/mL), NDR(409.65±50.37pg/mL), NPDR(535.67±69.21pg/mL)and PDR subgroup(551.60±103.46pg/mL)were significantly different(<i>F</i>=14.259, <i>P</i><0.01). Serum level of PDGF-BB in NPDR group and PDR group were higher compared to control group and NDR subgroup. Multiple regression analysis showed that serum level of PDGF-BB positively correlated with fasting blood glucose(FBG), triglycerides(TG)and stages of diabetes(<i>P</i><0.05). Serum level of PDGF-BB in PDR subgroup correlated with the thickness of macular(<i>r=</i>0.613, <i>P</i><0.05). Whereas, this correlation was not observed in other groups(<i>r_C=</i>0.013, <i>r_NDR=</i>0.051,<i> r_NPDR=</i>0.062; <i> P</i>>0.05).<p>CONCLUSION: Serum PDGF-BB level was observed to rise with severity of DR and relevant to macula edema. It was also positively correlated to FPG, TG and stages of diabetes. PDGF-BB could be recommended as diagnostic biomarker for DR.