Research progress on free radicals in human body / 中华流行病学杂志

ABSTRACT

Free radicals are the intermediates of metabolism,widely exist in the human bodies.Under normal circumstances,the free radicals play an important role in the metabolic process on human body,cell signal pathway,gene regulation,induction of cell proliferation and apoptosis,so as to maintain the normal growth and development of human body and to inhibit the growth of bacteria,virus and cancer.However,when organic lesion occurs affected by external factors or when equilibrium of the free radicals is tipped in the human body,the free radicals will respond integratedly with lipids,protein or nucleic acid which may jeopardize the health of human bodies.This paper summarizes the research progress of the free radicals conducted in recent years,in relations to the perspective of the types,origins,test methods of the free radicals and their relationship with human's health.In addition,the possible mechanisms of environmental pollutants (such as polycyclic aromatic hydrocarbons) mediating oxidative stress and free radicals scavenging in the body were also summarized.