Meta analysis on HBsAg-positive rate among general populations aged 1-59 years, 2007-2016,China / 中华流行病学杂志

ABSTRACT

Objective To perform a Meta-analysis on hepatitis B surface antigen (HBsAg)-positive rates among general Chinese population aged 1-59 years.Methods We systemically reviewed the related data (January 2007 to August 2016) published from Chinese National Knowledge Infrastructure (CNKI),VIP,and PubMed.We also assessed the HBsAg-positive rates among general Chinese populations aged 1-59 years,using a random effects regression model with the comprehensive Meta-analysis software 2.2.Results A total of 46 papers were finally included,with a total sample size of 625 053 individuals.Results from the Meta-analysis showed that the overall combined HBsAg-positive rate was 5.7％ (95％CI4.8％-6.6％) among general Chinese populations aged 1-59 years.When comparing the HBsAg-positive rates in different regions,data showed that the HBsAg-positive rate of was higher in the mid-western areas (6.3％,95％CI4.9％-8.0％)than in the eastern areas (5.5％,95％CI4.4％-6.8％).Results showed that HBsAg-positive rates was higher in males (6.1％,95％CI5.3％-7.0％) than in females (4.8％,95％CI4.2％-5.5％).As for the HBsAg-positive rates in different time periods,data showed positive rate of 6.3％ (95％CI5.5％-7.2％)in 2007-2009,5.9％ (95％CI4.4％-8.0％) in 2010-2012 and 3.5％ (95％CI2.0％-6.1％) in 2013-2016,respectively.Conclusion The prevalence of hepatitis B virus infection was decreasing between 2007 and 2016 in China,making the country an intermediate endemic area on HBV.