Effects of nordihydroguaiaretic acid on the expression of GFAP gene of human malignant glioma cell line SHG-44 / 第三军医大学学报
Journal of Third Military Medical University
; (24): 254-256, 2001.
Article
in Zh
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| ID: wpr-736942
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ABSTRACT
Objective To investigate the expression of glial fibrillary acidic protein (GFAP) gene and its significance in the process of glioma cell differentiation induced by nordihydroguaiaretic acid (NDGA). Methods Immunohistochemistry (IHC) and in situ hybridization were used to detect the expression changes of GFAP protein and GFAP mRNA qualitatively and quantitatively. Results The expression levels of GFAP protein and GFAP mRNA in NDGA treatment group were significantly increased compared with the control group (P<0.01). Conclusion NDGA could induce GFAP gene in malignant glioma cells and the up-regulation of this gene expression might be one of the mechanisms by which NDGA induces glioma differentiation.
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Language:
Zh
Journal:
Journal of Third Military Medical University
Year:
2001
Type:
Article