A Case of Clozapine-induced Corneal and Lenticular Pigmentation
Journal of the Korean Ophthalmological Society
;
: 276-279, 2019.
Article
in Korean
| WPRIM
| ID: wpr-738608
ABSTRACT
PURPOSE:
To report a case of corneal and lenticular pigmentation after prolonged clozapine therapy. CASESUMMARY:
A 56-year-old male visited our hospital with a progressive decline in vision that affected both eyes. He had a history of schizophrenia. He was being treated with 200 mg clozapine and 1 mg lorazepam daily, and had been treated with clozapine for 5 years. At the first visit, his best-corrected-visual acuity was 20/32 in both eyes. Slit lamp examination of the corneas showed bright, fine, grayish-brown deposits on the endothelium, and on dilation, bilateral central stellate opacity of the anterior portion of the lens capsule was revealed.CONCLUSIONS:
Clozapine may induce corneal and lenticular pigmentation and thus may lead to a decline in vision. Patients on long-term clozapine therapy should be considered for regular ophthalmic review.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Pigmentation
/
Clozapine
/
Cornea
/
Endothelium
/
Slit Lamp
/
Lorazepam
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2019
Type:
Article
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