Your browser doesn't support javascript.
loading
ABSTRACT
BACKGROUND AND OBJECTIVES: We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea. METHODS: This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0.9, 2) lower-extremity artery stenosis on computed tomography angiography ≥50%, or 3) peak-systolic-velocity-ratio (PSVR) on ultrasound ≥2.0. Medical chart review was used to assess patient characteristics/treatment patterns while the history of medical resource consumption and QoL data were collected using a patient survey. QoL was measured using EuroQoL-5-dimensions-3-level (EQ-5D-3L) score system, and the factors associated with QoL were analyzed using multiple linear regression analysis. RESULTS: This study included 1,260 patients (age: 69.8 years, male: 77.0%). The most prevalent comorbidities were hypertension (74.8%), hyperlipidemia (51.0%) and diabetes-mellitus (50.2%). The 94.1% of the patients took pharmacotherapy including aspirin (76.2%), clopidogrel (53.3%), and cilostazol (33.6%). The 12.6% of the patients were receiving smoking cessation education/pharmacotherapy. A considerable number of patients (500 patients, 40.0%) had visit history to another hospital before diagnosis/treatment at the current hospital, with visits to orthopedic units (50.4%) being the most common. At the time, 29% (or higher) of the patients were already experiencing symptoms of critical limb ischemia. Baseline EQ-5D index and EQ VAS were 0.64±0.24 and 67.49±18.29. Factors significantly associated with QoL were pharmacotherapy (B=0.05053; p=0.044) compared to no pharmacotherapy, and Fontaine stage improvement/maintain stage I (B=0.04448; p < 0.001) compared to deterioration/maintain stage II–IV. CONCLUSIONS: Increase in disease awareness for earlier diagnosis and provision of adequate pharmacotherapy is essential to reduce disease burden and improve QoL of Korean PAD patients.
Subject(s)
Key words
Full text: 1 Index: WPRIM Main subject: Orthopedics / Arteries / Quality of Life / Angiography / Comorbidity / Linear Models / Aspirin / Prospective Studies / Ultrasonography / Smoking Cessation Type of study: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Adult / Humans / Male Country/Region as subject: Asia Language: En Journal: Korean Circulation Journal Year: 2018 Type: Article
Full text: 1 Index: WPRIM Main subject: Orthopedics / Arteries / Quality of Life / Angiography / Comorbidity / Linear Models / Aspirin / Prospective Studies / Ultrasonography / Smoking Cessation Type of study: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Adult / Humans / Male Country/Region as subject: Asia Language: En Journal: Korean Circulation Journal Year: 2018 Type: Article