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A Retrospective Study of Clinical Response Predictors in Subcutaneous Allergen Immunotherapy With House Dust Mites for Allergic Rhinitis
Article in En | WPRIM | ID: wpr-739391
Responsible library: WPRO
ABSTRACT
PURPOSE: House dust mites (HDM) are major allergens that cause allergic rhinitis (AR). Allergen-specific subcutaneous immunotherapy (SCIT) has been shown to be clinically beneficial in many clinical trials. Such trials, however, are not reflective of all patient populations. The aim of this study was to describe the efficacy and safety of SCIT in routine clinical practice in Korean adults with AR sensitized to HDM. METHODS: We reviewed medical records of 304 patients with AR treated at an allergy clinic of a tertiary hospital using SCIT with aluminum hydroxide-adsorbed allergen extract targeting HDM alone or with pollens for at least 1 year from 2000 to 2012. Patients with asthma were excluded. Rates of remission, defined as no further requirement of maintenance medication, over time were determined by means of life tables and extension of survival analysis. Specific immunoglobulin E (IgE) levels to HDM were categorized into 6 classes. RESULTS: The mean time until achieving remission was 4.9±0.1 years, and the cumulative incidence of remission from AR was 76.6%. Severe AR (odds ratio [OR], 0.40; 95% confidence interval [CI], 0.23-0.69; P=0.001), specific IgE levels to HDM ≥17.5 kU/L (OR, 1.85; 95% CI, 1.01-3.37; P=0.045), and duration of immunotherapy ≥3 years (OR, 7.37; 95% CI, 3.50-15.51; P<0.001) were identified as significant predictors of clinical remission during SCIT for patients with AR sensitized to HDM. Overall, 73 patients (24.0%) experienced adverse reactions to SCIT, and only 1 case of anaphylaxis (0.3%) developed. CONCLUSIONS: SCIT with HDM was found to be effective and safe for patients with AR. Specific IgE levels to HDM and a duration of SCIT ≥3 years may be predictors of clinical responses to SCIT in AR patients.
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Full text: 1 Index: WPRIM Main subject: Pollen / Asthma / Immunoglobulin E / Immunoglobulins / Allergens / Medical Records / Incidence / Retrospective Studies / Life Tables / Desensitization, Immunologic Type of study: Incidence_studies / Observational_studies / Prognostic_studies Limits: Adult / Humans Language: En Journal: Allergy, Asthma & Immunology Research Year: 2018 Type: Article
Full text: 1 Index: WPRIM Main subject: Pollen / Asthma / Immunoglobulin E / Immunoglobulins / Allergens / Medical Records / Incidence / Retrospective Studies / Life Tables / Desensitization, Immunologic Type of study: Incidence_studies / Observational_studies / Prognostic_studies Limits: Adult / Humans Language: En Journal: Allergy, Asthma & Immunology Research Year: 2018 Type: Article