Soluble Dipeptidyl Peptidase-4 Levels Are Associated with Decreased Renal Function in Patients with Type 2 Diabetes Mellitus
Diabetes & Metabolism Journal
; : 97-104, 2019.
Article
in En
| WPRIM
| ID: wpr-739791
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) is strongly expressed in the kidney, and soluble levels of this protein are used as a marker in various chronic inflammatory diseases, including diabetes, coronary artery disease, and cancer. This study examined the association between the serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus. METHODS: In this retrospective analysis, soluble DPP-4 levels were measured in preserved sera from 140 patients with type 2 diabetes mellitus who had participated in our previous coronary artery calcium (CAC) score study. RESULTS: The mean±standard deviation soluble DPP-4 levels in our study sample were 645±152 ng/mL. Univariate analyses revealed significant correlations of soluble DPP-4 levels with the total cholesterol (r=0.214, P=0.019) and serum creatinine levels (r=−0.315, P<0.001) and the estimated glomerular filtration rate (eGFR; estimated using the modification of diet in renal disease equation) (r=0.303, P=0.001). The associations of soluble DPP-4 levels with serum creatinine and GFR remained significant after adjusting for age, body mass index, and duration of diabetes. However, no associations were observed between soluble DPP-4 levels and the body mass index, waist circumference, or CAC score. CONCLUSION: These data suggest the potential use of serum soluble DPP-4 levels as a future biomarker of deteriorated renal function in patients with type 2 diabetes mellitus.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Coronary Artery Disease
/
Body Mass Index
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Calcium
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Cholesterol
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Retrospective Studies
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Dipeptidyl Peptidase 4
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Coronary Vessels
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Creatinine
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Diabetes Mellitus, Type 2
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Diet
Type of study:
Observational_studies
Limits:
Humans
Language:
En
Journal:
Diabetes & Metabolism Journal
Year:
2019
Type:
Article