Tissue-specific Role of CX₃CL1 Expressing Immune Cells and Their Relationships with Human Disease
Immune Network
; : e5-2018.
Article
in En
| WPRIM
| ID: wpr-740204
Responsible library:
WPRO
ABSTRACT
Chemokine (C-X3-C motif) ligand 1 (CX₃CL1, also known as fractalkine) and its receptor chemokine (C-X3-C motif) receptor 1 (CX₃CR1) are widely expressed in immune cells and non-immune cells throughout organisms. However, their expression is mostly cell type-specific in each tissue. CX₃CR1 expression can be found in monocytes, macrophages, dendritic cells, T cells, and natural killer (NK) cells. Interaction between CX3CL1 and CX₃CL1 can mediate chemotaxis of immune cells according to concentration gradient of ligands. CX₃CL1 expressing immune cells have a main role in either pro-inflammatory or anti-inflammatory response depending on environmental condition. In a given tissue such as bone marrow, brain, lung, liver, gut, and cancer, CX₃CL1 expressing cells can maintain tissue homeostasis. Under pathologic conditions, however, CX₃CL1 expressing cells can play a critical role in disease pathogenesis. Here, we discuss recent progresses of CX3CL1/CX₃CL1 in major tissues and their relationships with human diseases.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Organ Specificity
/
Bone Marrow
/
Dendritic Cells
/
Brain
/
Monocytes
/
T-Lymphocytes
/
Chemotaxis
/
Chemokine CX3CL1
/
Homeostasis
/
Ligands
Limits:
Humans
Language:
En
Journal:
Immune Network
Year:
2018
Type:
Article