Effect of Sasa quelpaertensis Nakai Extracts and its Constituent p-coumaric Acid on the Apoptosis of Human Cancer Cell Lines
Natural Product Sciences
;
: 293-297, 2018.
Article
in English
| WPRIM
| ID: wpr-741627
ABSTRACT
Sasa quelpaertensis Nakai leaves contain a mixture of polysaccharides, amino acids, and polyphenols, which mediate various biological activities. For efficient utilization of its leaf, we reported the preparation procedure for phytochemical-rich extract (PRE) using the leaf residue, which was by-product of hot water extraction. This study was undertaken to evaluate the effects of PRE and its major constituent, p-coumaric acid,on the growth of several human cancer cell lines (MKN-74, MKN-45, SNU-1, SNU-16, and HL-60). The ethyl acetate fraction of PRE and p-coumaric acid significantly inhibited the proliferation of MKN-74 and HL-60 cells, respectively, and induced cell apoptosis, down-regulated Bcl-2 and poly (ADP-ribose) polymerase levels, and up-regulated those of Bax and caspase-3. These results show the potential utility of S. quelpaertensis Nakai leaves in cancer prevention.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polysaccharides
/
Water
/
Cell Line
/
Apoptosis
/
HL-60 Cells
/
Sasa
/
Caspase 3
/
Polyphenols
/
Phytochemicals
/
Amino Acids
Limits:
Humans
Language:
English
Journal:
Natural Product Sciences
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS