Biological and Clinical Markers in Panic Disorder
Psychiatry Investigation
; : 27-36, 2019.
Article
in En
| WPRIM
| ID: wpr-741921
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
Classifying mental disorders on the basis of objective makers might clarify their aetiology, help in making the diagnosis, identify “at risk” individuals, determine the severity of mental illness, and predict the course of the disorder. This study aims to review biological and clinical markers of panic disorder (PD).METHODS:
A computerized search was carried out in PubMed and Science Direct using the key words “marker/biomarker/clinical marker/neurobiology/staging” combined using Boolean AND operator with “panic.” In addition, the reference lists from existing reviews and from the articles retrieved were inspected. Only English language papers published in peer-reviewed journals were included.RESULTS:
Structural changes in the amygdala, hippocampus, cerebral blood level in the left occipital cortex, serotonin 5-TH and noradrenergic systems activation, aberrant respiratory regulation, hearth rate variability, blood cells and peripheral blood stem cells, hypothalamic–pituitary–adrenal axis dysregulation were identified as potential candidate biomarkers of PD. Staging was identified as clinical marker of PD. According to the staging model, PD is described as follows prodromal phase (stage 1); acute phase (stage 2); panic attacks (stage 3); chronic phase (stage 4).CONCLUSION:
The clinical utility, sensitivity, specificity, and the predictive value of biomarkers for PD is still questionable. The staging model of PD might be a valid susceptibility, diagnostic, prognostic, and predictive marker of PD. A possible longitudinal model of biological and clinical markers of PD is proposed.Key words
Full text:
1
Index:
WPRIM
Main subject:
Panic
/
Stem Cells
/
Blood Cells
/
Biomarkers
/
Serotonin
/
Sensitivity and Specificity
/
Panic Disorder
/
Diagnosis
/
Prodromal Symptoms
/
Hippocampus
Type of study:
Diagnostic_studies
/
Prognostic_studies
Language:
En
Journal:
Psychiatry Investigation
Year:
2019
Type:
Article