Comparison of effects of propylthiouracil and methimazole on pregnancy outcomes and glucose and lipid metabolism in patients with hyperthyroidism in pregnancy / 国际检验医学杂志

ABSTRACT

Objective To compare the effects of propylthiouracil and methimazole on pregnancy outcomes and glucose and lipid metabolism in patients with hyperthyroidism in pregnancy, and to analyze the security.Methods Totally 92patients with hyperthyroidism in pregnancy were divided into the observation group (46cases) and control group (46cases).Patients in both groups were given routine adjuvant therapy, such asβ-blocker, liver protection, increasing white blood cells.The patients in observation group were treated with propylthiouracil while the patients in control group were treated with methimazole.The thyroxine levels (TSH, T3, T4, FT3, FT4), pregnancy outcomes, glucose and lipid metabolism (FPG, FINS, TC, TG), liver function indicators (ALT, ALP, AST) and maternal complications of two groups were compared after treatment for 3months.Results The TSH level of the observation group was significantly higher than that of the control group, and the T3, T4, FT3, FT4levels of the observation group were significantly lower than those of the control group (P＜0.05).The incidence of premature birth, miscarriage, intrauterine fetal death, fetal distress and gestational hypertension of observation group were significantly lower than those of the control group, but the incidence of full-term production of observation group was significantly higher than that of the control group (P＜0.05).The FPG, FINS, TC and TG levels of the observation group were significantly lower than those of the control group (P＜0.05).The increased amplitude of ALT, ALP, AST of the observation group were significantly lower than those of the control group (P＜0.05).There were puerperal infection, hyperthyroid heart disease, diabetes, oligohydramnios, placental abruption, pregnancy-induced hypertension and other complications occurred in both two groups, but the incidence of the observation group were significantly lower than those of the control group (P＜0.05).Conclusion Compared with methimazole, propylthiouracil is more beneficial to improve thyroid function, pregnancy outcome and glucose and lipid metabolism in patients with hyperthyroidism in pregnancy, and has higher security.