Expression and clinical significance of N-Myc and p53 in prostate cancer tissues / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
; (12): 10-13, 2019.
Article
in Zh
| WPRIM
| ID: wpr-743331
Responsible library:
WPRO
ABSTRACT
Purpose To detect the expression of N-Myc and p53 in the tissues of prostate cancer (PCa) patients and to explore the relationship between them and their significance.Methods A total of 63 patients with PCa and 50 patients with benign prostatic hyperplasia (BPH) who underwent prostate surgery at the First Affiliated Hospital of Anhui Medical University were recruited in 2015-2016. The expression of N-Myc and p53 in pathological tissues were detected by immunohistochemistry of MaxVision method. Results The expression of N-Myc and p53 in PCa tissues was increased (P < 0.05). The expression of N-Myc and p53 in PCa tissues was correlated with bone metastases and TNM stage (P < 0.05), but not related to patient age, preoperative PSA level and other factors (P> 0.05). In addition, the expression of p53 was also correlated with Gleason score.Conclusion The high expression of N-Myc and p53 in PCa may involved in the malignant progression and metastasis of prostate cancer, and it is expected to become a new target for detecting PCa metastasis.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Clinical and Experimental Pathology
Year:
2019
Type:
Article