Analysis of the levels of serum 25-hydroxy vitamin D in autumn and winter among children of Shenmu city,Shaanxi province / 中国基层医药

ABSTRACT

Objective To investigate the levels of serum 25-hydroxy vitamin D in autumn and winter among children of Shenmu city,Shaanxi province,and to provide theoretical basis for prevention and treatment of rickets in this area.Methods From June 2016 to December 2016,a total of 277 children in the children's health clinic were sleceted.The morning fasting blood was extracted and serum levels of 25-hydroxy vitamin D were measured by enzyme-linked immunosorbent assay (ELISA).Results Among the 277 cases,there were 181 males and 96 females,including 163 infants(58.8％),75 toddlers(27.1％),24 preschool children(8.7％) and 15 school-going children(5.4％).The median (interquartile range) of serum 25-hydroxyl vitamin D was 33.21 (14.93)nmol/L.Among all children,4.3％ had severe vitamin D deficiency,15.9％ had moderate deficiency,57.0％ had mild deficiency,7.9％ had insufficient vitamin D levels,11.9％ had suitable vitamin D levels,while 2.9％ had excess of vitamin D.There was no statistically significant difference in the level of 25-hydroxyl vitamin D between different age groups(H =10.133,P ＞0.05),and different gender groups(Z =0.712,1.094,0.476,0.000,all P ＞0.05).The levels of serum 25-hydroxyl vitamin D in serum extracted in autumn were higher than those extracted in winter(75.96％ vs.90.75％,x2 =11.27,P ＜0.05).Conclusion There is significant deficiency of serum 25-hydroxyl vitamin D in Shenmu children,which significantly increased in winter.The outdoor activities should be strengthened and the vitamin D should be timely supplemented to prevent the occurrence of rickets.