Correlation of serum vitamin D with serum lipid in middle-aged and elderly people / 中华临床营养杂志

ABSTRACT

Objective To investigate the correlation of serum 25-hydroxy-vitamin D (25-OH-D) with lipid profiles in middle-aged and elderly patients.Methods A total of 284 patients aged over 40 years and admitted in our hospital from May 2016 to May 2017 were selected and divided into four groups according to 25-OH-D levels as the group of normal level which was not less than 30 ng/ml,the group of slight deficiency which was between 20 and 29 ng/ml,the group of moderate deficiency which was between 10 and 19 ng/ml,and the group of severely deficiency which was under 10 ng/ml.Fasting blood draw were taken to detect liver and renal functions,lipids,calcium,phosphorus and 25-OH-D levels.The level of lipids between groups was compared by one-way ANOVA,and the association between lipid profiles and 25-OH-D levels was assessed by Pearson correlation and multiple linear regression.Results The levels of triglyceride (TG),low density lipoprotein cholesterin (LDL-C) and total cholesterol/high density lipoprotein cholesterol (TC/HDL-C) were significantly higher and the HDL-C levels were significantly lower in the groups of severely deficiency,moderate deficiency and slight deficiency than in the normal group (P=0.035,P=0.015,P=0.013).The levels of serum 25-OH-D were significantly higher in HDL-C ≥ 1.04 mmol/L group than in H DL-C＜ 1.04 mmol/L group (Female P =0.007,male P=0.034).The correlation analysis showed that serum 25-OH-D level was positively associated with HDL-C (female r =0.309,P=0.002,male r =0.241,P=0.002).The multiple linear regression analysis showed that 25-OH-D level was positively correlated with HDL-C,after adjusting age,BMI,liver and kidney function,serum calcium and serum phosphorus (femaleβ =0.259,P =0.047,maleβ =0.217,P =0.049).Conclusion The incidence of vitamin D deficiency is high in middle-aged and elderly patients,and the level of serum 25-OH-D is positively correlated with HDL-C.