Expression and clinical significance of serum vasohibin-1 in type 2 diabetes mellitus patients / 中国综合临床

ABSTRACT

Objective To investigate the expression and clinical significance of vasohibin-1 (VASH-1) in patients with type 2 diabetes mellitus.Methods From November 2015 to December 2017,four hundred and twenty-two patients with T2DM in Chaoyang Central Hospital were selected and divided into three groups according to the urinary albumin excretion rate (UACR)normal albuminuria group (UACR ＜30 mg/g,149 cases),microalbuminuria group (30 ≤ UACR ≤ 300 mg/g,143 cases),clinical albuminuria group(UACR＞300 mg/g,130 cases).Three hundred healthy subjects in Chaoyang Central Hospital during the same period were selected as control group.The levels of serum VASH-1 and transforming growth factor-β1 (TGF-β1) in each group were determined by enzyme linked immunosorbent assay.Results VASH-1 and TGF-β1 in diabetic group and control group were (579±236) ng/L,(350±141) ng/L and (18.92 ±2.21) μg/L,(5.69 ± 0.70) μg/L,respectively.There were significant differences between the two groups (t =4.721,6.142,P＜0.01).The serum VASH-1 levels in normal albuminuria group,microalbuminuria group and massive albuminuria group were (450+182) ng/L,(571±194) ng/L,(786±201) ng/L,and the serum TGF-β1 levels were (11.71 ± 1.81) μg/L,(14.02 ± 2.91) μg/L,(19.32 ± 1.97) μg/L,respectively.Compared with the normal albuminuria group,the serum VASH-1 and TGF-β1 levels in the microalbuminuria group and the massive albuminuria group were significantly higher (P＜0.05),and the serum VASH-1 and TGF-β1 levels in the massive albuminuria group were significantly higher than those in the microalbuminuria group,with significant difference between the two groups (P＜0.05).Multivariate linear regression analysis showed that serum VASH-1 level was positively correlated with TGF-β1 in diabetic patients (r=0.554,P=0.000).Conclusion With the progress of DN microangiopathy,the serum VASH-1 concentration in type 2 diabetes mellitus increased significantly through negative feedback to regulate and control the formation of neovascularization and delay renal interstitial fibrosis,so as to achieve the protection of the kidney.