Advances in proteomics in elderly patients with frailty / 中华老年医学杂志

ABSTRACT

With population aging,the number of elderly subjects with frailty is increasing,and frailty can lead to adverse clinical outcomes.Early screening,early diagnosis and early prevention and treatment of frailty have important clinical significance.Due to increasing demand for early screening,early diagnosis and prognosis assessment,preliminary screening for frailty based on characteristic changes in specific proteomics may be a promising diagnostic strategy.At present,most research mainly focuses on skeletal muscle proteomics,inflammatory proteomics and vascular system proteomics.This review will summarize and analyze recent proteomic studies on protein profiles of frailty and non-frailty subjects.