Expression and clinical significance of stromelysin-3 in laryngeal cancer / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 104-107, 2008.
Article
in Zh
| WPRIM
| ID: wpr-749101
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the role of expression of stromelysin-3 in laryngeal carcinoma and the relationship between stromelysin-3 expression and the invasion and metastasis of laryngeal cancer.@*METHOD@#The expression of stromelysin-3 in 63 samples with laryngeal carcinoma and 63 adjacent normal tissue were detected by immunohistochemistry. The mRNA expression of stromelysin-3 were examined by reverse transcript-polymerase chain reaction (RT-PCR) in 22 frozen specimens of laryngeal cancer and 22 adjacent normal tissue.@*RESULT@#The immunochemistry showed the expression of stromelysin-3 in laryngeal cancer is much higher than that in adjacent normal tissue (P 0.05).@*CONCLUSION@#The expression of stromelysin-3 was closely associated with the invasion and metastases of laryngeal carcinoma, it may be served as a marker in estimating the invasion and metastases potency of laryngeal cancer.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Biomarkers, Tumor
/
Laryngeal Neoplasms
/
Matrix Metalloproteinase 11
/
Lymphatic Metastasis
/
Metabolism
/
Neoplasm Invasiveness
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2008
Type:
Article