Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models
Asia Pacific Allergy
;
(4): 115-121, 2012.
Article
in English
| WPRIM
| ID: wpr-749899
ABSTRACT
BACKGROUND:
Olopatadine hydrochloride ophthalmic solutions are treated for allergic conjunctival diseases that are a selective histamine H1 receptor antagonist and an inhibitor of the release of mediators including histamine from the human mast cells. Substance P (SP) levels are increased in tears of patients with allergic conjunctivitis. However, little is known about the regulation of SP release by anti-allergic ophthalmic solutions.OBJECTIVE:
We investigated that the effect of olopatadine hydrochloride ophthalmic solutions (olopatadine 0.1% and olopatadine 0.2%) on rat conjunctivitis models compared with other anti-allergic ophthalmic solutions.METHODS:
Conjunctivitis was induced by subconjunctival injection of histamine or intravenous injection of ovalbumin in rats passively sensitized with anti-ovalbumin anti-serum. The releases of SP were determined in the conjunctiva and tears using rat antigen-induced conjunctivitis models.RESULTS:
Olopatadine 0.1% and 0.2% significantly inhibited the increased conjunctival dye leaked in the histamine- or antigen-induced hyperpermeability. The inhibitory effects by olopatadine were more potent than by other tested anti-allergic ophthalmic solutions. Moreover, olopatadine significantly inhibited the release of SP from the conjunctiva.CONCLUSION:
These results indicate that olopatadine ophthalmic solutions appear to exert additional SP release inhibition besides dual-action such as selective histamine H1 receptor antagonistic action and mast cell stabilization action.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ophthalmic Solutions
/
Tears
/
Conjunctivitis, Allergic
/
Receptors, Histamine H1
/
Histamine
/
Substance P
/
Ovalbumin
/
Conjunctiva
/
Conjunctival Diseases
/
Conjunctivitis
Limits:
Animals
/
Humans
Language:
English
Journal:
Asia Pacific Allergy
Year:
2012
Type:
Article
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