Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis
Asia Pacific Allergy
; (4): 236-244, 2016.
Article
in En
| WPRIM
| ID: wpr-750078
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Imidacloprid has been commonly used as a pesticide for crop protection and acts as nicotinic acetylcholine receptor agonists. Little information about the relationship between imidacloprid and allergy is available.OBJECTIVE:
This study aims to examine the effects of imidacoprid on IgE-mediated mast cell activation.METHODS:
The rat basophilic leukemia cell line RBL-2H3 (RBL-2H3 cells) were treated with 10⁻³ – 10⁻¹² mol/L imidacloprid, followed by measuring the mediator production, influx of Ca²⁺ in IgE-activated RBL-2H3 cells, and the possible effects of imidacoprid on anti-dinitrophenyl IgE-induced passive cutaneous anaphylaxis (PCA).RESULTS:
It was shown that imidacoprid suppressed the production of histamine, β-hexosaminidase, leukotriene C4, interleukin-6, tumor necrosis factor-α, and Ca²⁺ mobilization in IgE-activated RBL-2H3 cells and decreased vascular extravasation in IgE-induced PCA.CONCLUSION:
It is the first time to show that imidacloprid suppressed the activation of RBL-2H3 cells.Key words
Full text:
1
Index:
WPRIM
Main subject:
Basophils
/
Passive Cutaneous Anaphylaxis
/
Leukemia
/
Histamine
/
Cell Degranulation
/
Cell Line
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Interleukin-6
/
Receptors, Nicotinic
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Leukotriene C4
/
Crop Protection
Limits:
Animals
Language:
En
Journal:
Asia Pacific Allergy
Year:
2016
Type:
Article