Impact of high serum Immunoglobulin E levels on the risk of atherosclerosis in humans
Asia Pacific Allergy
; (4): 74-81, 2017.
Article
in En
| WPRIM
| ID: wpr-750099
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Epidemiological studies show that immunoglobulin E (IgE) levels were higher in subjects with acute coronary events. However, it is unknown if the increased IgE level is a marker of future coronary incidents and whether it may be regarded as a risk factor of an ischemic heart disease.OBJECTIVE:
Our aim was to investigate the relationship between IgE levels and some atherosclerotic markers in patients without known atherosclerotic disease.METHODS:
Fifty patients (mean age, 40.96 ± 10.8 years) with high serum IgE levels due to various conditions who did not display evidence of an atherosclerotic disease and 30 healthy control subjects (mean age, 47 ± 8.27 years) were included in the study. Atherosclerotic disease markers including adhesion molecules like vascular cell adhesion molecule-1, intercellular adhesion molecule-1, proinflammatory cytokines such as interleukin-6, endothelin-1, and systemic inflammatory markers such as high sensitivity C-reactive protein were determined by enzyme-linked immunosorbent assay (ELISA). Endothelial functions of the coronary arteries were determined by coronary flow reserve (CFR) measurements and carotid intima media thickness using transthoracic Doppler echocardiography.Key words
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
C-Reactive Protein
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Immunoglobulin E
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Immunoglobulins
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Enzyme-Linked Immunosorbent Assay
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Echocardiography, Doppler
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Epidemiologic Studies
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Risk Factors
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Cytokines
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Interleukin-6
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Asia Pacific Allergy
Year:
2017
Type:
Article