Research progress on prevention and treatment of ischemia-reperfusion injury in intestinal transplantation / 中国医师杂志

ABSTRACT

Intestinal transplantation is the only treatment option for irreversible intestinal failure and parenteral nutrition failure.Although the progress of immunosuppressive therapy and the improvement of surgical techniques have improved the prognosis of intestinal transplantation,it is still unsatisfactory compared with other solid organ transplantation,mainly due to the fact that the intestinal mucosa is susceptible to damage due to ischemia.The basic pathophysiological process of ischemia-reperfusion injury(IRI) is that ischemia/reperfusion induces the production of reactive oxygen species (ROS),inflammation and cell apoptosis,leading to tissue damage.In recent years,the pathophysiology of ischemia-reperfusion injury in intestinal transplantation has made some new progress,providing more possibilities for the prevention and treatment of intestinal transplantation IRI.Although most of them are animal experimental results,they have important reference value for clinical application.