Research progress of S1PR1 in tumor metastasis-promoting and radiotherapy resistance / 中华放射医学与防护杂志
Chinese Journal of Radiological Medicine and Protection
;
(12): 599-602, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-755015
ABSTRACT
Distant metastasis is one of the main obstacles to cancer treatment.Overexpression of S1PR1 in malignant tumors enhances cell invasion and migration activity,mediates EMT and induces lymphangiogenesis and angiogenesis via activation of its downstream signaling pathways,eventually results in the occurrence of tumor metastasis.S1PR1 is also closely related to generation of acquired radiotherapy resistance.This article discusses the roles of S1PR1 in tumor metastasis and radiotherapy resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Radiological Medicine and Protection
Year:
2019
Type:
Article
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