BK virus infection and urothelial carcinoma after renal transplantation / 中华器官移植杂志
Chinese Journal of Organ Transplantation
; (12): 98-101, 2019.
Article
in Zh
| WPRIM
| ID: wpr-755904
Responsible library:
WPRO
ABSTRACT
Objective To explore the potential role of BK virus (BKV) in urothelial carcinoma after renal transplantation .Methods From May 2013 to March 2017 , We collected 26 cases of urothelial carcinoma after renal transplantation (study group) and 30 cases of urothelial carcinoma of non-immunosuppressed patients (control group) .Tumor tissues were stained with SV40 T antigen by immunohistochemical assay .Urinary and peripheral blood samples were assayed for BKV-DNA levels by real-time fluorescent quantitative polymerase chain reaction (PCR) .Results There were 7 positive cases of SV40 T-Ag in study group and only 1 weakly positive case in control group .The positive rate of BKV-DNA was 38 .5% in urinary samples in study group (10 /26 ) and it was significantly higher than that in control group by 10% (3/30)(P< 0 .05) .And the positive rate of blood BKV-DNA was not different between two groups ( P > 0 .05 ) .Conclusions There is a relatively high prevalence of BKV infection in urothelial carcinoma after renal transplantation .And a ,high level of BKV infection may play a role in urothelial carcinoma after renal transplantation .
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Organ Transplantation
Year:
2019
Type:
Article