USP33, a new player in lung cancer, mediates Slit-Robo signaling
Protein & Cell
;
(12): 704-713, 2014.
Article
in English
| WPRIM
| ID: wpr-757656
ABSTRACT
Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Prognosis
/
Immunohistochemistry
/
Receptors, Immunologic
/
Signal Transduction
/
Down-Regulation
/
Gene Expression Regulation, Neoplastic
/
Cell Movement
/
Blotting, Western
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Protein & Cell
Year:
2014
Type:
Article
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