Risk Factors for Adverse Events of Therapeutic Plasma Exchange Assessed in a Single Center Study / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 148-155, 2019.
Article
in Ko
| WPRIM
| ID: wpr-759591
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Therapeutic plasma exchange (TPE) is used to remove pathologic substances involved in various disease etiologies. The use of TPE is increasing steadily in a variety of disease. This study analyzed the incidence, type and severity of adverse events (AE) according to the initial TPE of each patient in a single center. The risk factors for AE of TPE were also elucidated.METHODS:
The medical and laboratory records of patients, who received TPE from January 2014 to December 2018, were reviewed retrospectively. The signs or symptoms during and after TPE were analyzed.RESULTS:
TPE sessions were performed on 95 patients. The mean age was 53.3 years and men comprised 63.2%. The most common indication for TPE was desensitization for ABO-incompatible liver transplantation (ABO-i LT) (N=56, 58.9%). A total of 27 patients (28.4%) experienced AE during the initial TPE. The types of AE were allergic reactions (N=14, 14.7%), anaphylactic reaction (N=3, 11.1%), hypotension (N=5, 5.3%), hypocalcemic reaction (N=4, 4.2%), and febrile nonhemolytic reaction (N=1, 1.1%). The severities of AE were evaluated as mild in eight procedures (8.4 %), moderate in seventeen (17.9 %), and severe in two (2.1 %). Multivariable logistic regression analysis showed that the desensitization for ABO-i LT (odds ratio (OR), 2.08; 95% CI, 1.03~4.22) and the amount of FFP (OR, 1.07; 95% CI, 1.01~1.09) were associated with a higher incidence of AE.CONCLUSION:
TPE can be performed under careful patient monitoring to provide prompt intervention, particularly in patients with desensitization of ABO-i LT using FFP.Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Plasma Exchange
/
Logistic Models
/
Incidence
/
Retrospective Studies
/
Risk Factors
/
Liver Transplantation
/
Hypersensitivity
/
Hypotension
/
Anaphylaxis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Humans
/
Male
Language:
Ko
Journal:
Korean Journal of Blood Transfusion
Year:
2019
Type:
Article