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Three Fibrotic Conditions Treated with 5% Topical Imiquimod Cream as an Antifibrotic Agent / 대한피부과학회지
Article in Ko | WPRIM | ID: wpr-759729
Responsible library: WPRO
ABSTRACT
Imiquimod, a toll-like receptor agonist, is a topical immunomodulator that induces the production of several cytokines including interferon-alpha, which shows antifibrotic properties. We hypothesized that the antifibrotic effect of imiquimod would soften fibrotic skin lesions. Therefore, we applied topical imiquimod with topical tacrolimus or systemic acitretin in patients with refractory lesions of myxedema, angiolymphoid hyperplasia, and generalized discoid lupus erythematosus and confirmed improvement in fibrotic lesions in these patients. Thus, we conclude that use of imiquimod improves fibrotic skin lesions. This report describes our experience with the treatment of this condition along with a review of the related literature.
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Full text: 1 Index: WPRIM Main subject: Skin / Fibrosis / Lupus Erythematosus, Discoid / Cytokines / Interferon-alpha / Tacrolimus / Acitretin / Toll-Like Receptors / Hyperplasia / Angiolymphoid Hyperplasia with Eosinophilia Limits: Humans Language: Ko Journal: Korean Journal of Dermatology Year: 2019 Type: Article
Full text: 1 Index: WPRIM Main subject: Skin / Fibrosis / Lupus Erythematosus, Discoid / Cytokines / Interferon-alpha / Tacrolimus / Acitretin / Toll-Like Receptors / Hyperplasia / Angiolymphoid Hyperplasia with Eosinophilia Limits: Humans Language: Ko Journal: Korean Journal of Dermatology Year: 2019 Type: Article