Malignization of Oral Leukoplakia and the Need for Early Excisional Biopsy / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 108-113, 2019.
Article
in Ko
| WPRIM
| ID: wpr-760094
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
Cancer of the oral cavity is a disease of the head and neck that is difficult to treat. Periodic observation and biopsy are important for its early diagnosis once a premalignant lesion in the oral cavity is confirmed. The purpose of this study was to determine the importance of early excisional biopsy by investigating the histological features of oral leukoplakia and the rate of malignant change in the oral cavity. SUBJECTS ANDMETHOD:
A total of 327 patients who underwent punch biopsy of oral cavity from January 2011 to December 2017 were reviewed retrospectively for the presence of initial gross lesions and for their biopsy results. The histological findings of 6 initial gross lesion groups were compared. Additional excisional biopsies were performed in the seven oral cavity subsites.RESULTS:
There were 33 cases of oral leukoplakia. The punch biopsies of 3 of these cases (9.1%) showed malignancy. Additional excisional biopsies were performed in 6 cases, 4 of which were malignant (66.7%). Additional excisional biopsies of the tongue were performed in 14 cases (9.0%), 5 of which (35.7%) were malignant. The rate of atypia in leukoplakia (9.1%) was higher than in other atypia groups. Additional excisional biopsies were performed in 3 cases (100%) of atypia of leukoplakia, all of which were assessed to be malignant.CONCLUSION:
For tongue leukoplakia, performing an early excisional biopsy rather than an incisional biopsy is recommendable. Moreover, additional excisional biopsies are needed when the initial biopsy is suggestive of hyperkeratosis, parakeratosis, or atypia.Key words
Full text:
1
Index:
WPRIM
Main subject:
Parakeratosis
/
Tongue
/
Biopsy
/
Leukoplakia, Oral
/
Retrospective Studies
/
Early Diagnosis
/
Head
/
Leukoplakia
/
Methods
/
Mouth
Type of study:
Diagnostic_studies
/
Observational_studies
/
Screening_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2019
Type:
Article