Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects
Obstetrics & Gynecology Science
; : 212-223, 2019.
Article
in En
| WPRIM
| ID: wpr-760654
Responsible library:
WPRO
ABSTRACT
Recurrent pregnancy loss (RPL) is a common complication in obstetrics, affecting about 5% of women of childbearing age. An increase in the number of abortions results in escalation in the risk of miscarriage. Although concentrated research has identified numerous causes for RPL, about 50% of them remain unexplained. Pregnancy is a complex process, comprising fertilization, implantation, organ and tissue differentiation, and fetal growth, which is effectively controlled by a number of both maternal and fetal factors. An example is the immune response, in which T cells and natural killer cells participate, and inflammation mediated by tumor necrosis factor or colony-stimulating factor, which hinders embryo implantation. Furthermore, vitamin D affects glucose metabolism and inhibits embryonic development, whereas microRNA has a negative effect on the gene expression of embryo implantation and development. This review examines the causes of RPL from multiple perspectives, and focuses on the numerous factors that may result in RPL.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Embryo Implantation
/
Vitamin D
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Killer Cells, Natural
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T-Lymphocytes
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Gene Expression
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Abortion, Spontaneous
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Abortion, Habitual
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Colony-Stimulating Factors
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Tumor Necrosis Factor-alpha
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MicroRNAs
Type of study:
Prognostic_studies
Limits:
Female
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Humans
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Pregnancy
Language:
En
Journal:
Obstetrics & Gynecology Science
Year:
2019
Type:
Article