Prospective Validation of The Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 1249-1256, 2019.
Article
in En
| WPRIM
| ID: wpr-763155
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The purpose of this study was to prospectively validate the Korean Cancer Study Group Geriatric Score (KG)-7, a novel geriatric screening tool, in older patients with advanced cancer planned to undergo first-line palliative chemotherapy. MATERIALS ANDMETHODS:
Participants answered the KG-7 questionnaire before undergoing geriatric assessment (GA) and first-line palliative chemotherapy. The performance of KG-7 was evaluated by calculating the sensitivity (SE), specificity (SP), positive and negative predictive value (PPV and NPV), balanced accuracy (BA), and area under the curve (AUC).RESULTS:
The baseline GA and KG-7 results were collected from 301 patients. The median age was 75 years (range, 70 to 93 years). Abnormal GA was documented in 222 patients (73.8%). Based on the ≤ 5 cut-off value of KG-7 for abnormal GA, abnormal KG-7 score was shown in 200 patients (66.4%). KG-7 showed SE, SP, PPV, NPV, and BA of 75.7%, 59.7%, 84.4%, 46.0%, and 67.7%, respectively; AUC was 0.745 (95% confidence interval, 0.687 to 0.803). Furthermore, patients with higher KG-7 scores showed significantly longer survival (p=0.006).CONCLUSION:
KG-7 appears to be adequate in identifying patients with abnormal GA prospectively. Hence, KG-7 can be a useful screening tool for Asian countries with limited resources and high patient volume.Key words
Full text:
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Index:
WPRIM
Main subject:
Geriatric Assessment
/
Mass Screening
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Prospective Studies
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Sensitivity and Specificity
/
Area Under Curve
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Asian People
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Drug Therapy
Type of study:
Diagnostic_studies
/
Observational_studies
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Prognostic_studies
/
Screening_studies
Limits:
Humans
Language:
En
Journal:
Cancer Research and Treatment
Year:
2019
Type:
Article