Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala
Experimental Neurobiology
; : 320-328, 2019.
Article
in En
| WPRIM
| ID: wpr-763772
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WPRO
ABSTRACT
The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning. However, the cholinergic mechanism at the circuit level has not been defined yet. We demonstrated that cholinergic-induced di-synaptic inhibition of BLA pyramidal neurons exhibits a retrograde form of short-term synaptic inhibition, depolarization-induced suppression of inhibition (DSI). Activation of nicotinic receptors was sufficient to evoke action potentials in cholecystokinin (CCK)-positive inhibitory neurons, which strongly inhibit pyramidal neurons through their perisomatic synapses. Our cell type-specific monosynaptic retrograde tracing also revealed that CCK neurons are innervated by basal forebrain cholinergic neurons. Therefore, our data indicated that CCK inhibitory neurons mediate the cholinergic-induced di-synaptic inhibition of BLA pyramidal neurons.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Synapses
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Action Potentials
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Cholecystokinin
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Acetylcholine
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Iontophoresis
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Receptors, Nicotinic
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Pyramidal Cells
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Conditioning, Operant
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Cholinergic Neurons
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Basolateral Nuclear Complex
Language:
En
Journal:
Experimental Neurobiology
Year:
2019
Type:
Article