Influence of Short- and Long-term High-dose Caffeine Administration on Behavior in an Animal Model of Adolescence
Journal of Korean Biological Nursing Science
; : 217-223, 2019.
Article
in En
| WPRIM
| ID: wpr-764750
Responsible library:
WPRO
ABSTRACT
PURPOSE: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction of energy drinks. However, little is known about the time-dependent effect of high doses of caffeine consumption in adolescents. The present study aims to examine the short- and long-term influence of high-dose caffeine on behavior of adolescence. METHODS: The animals were divided into three groups: a “vehicle” group, which was injected with 1 ml of phosphate-buffered saline for 14 days; a “Day 1” group, which was injected with caffeine (30 mg/kg), 2 h before the behavioral tests; and a “Day 14” group, which was infused with caffeine for 14 days. An open-field test, a Y-maze test, and a passive avoidance test were conducted to assess the rats'activity levels, anxiety, and cognitive function. RESULTS: High-dose caffeine had similar effects in short-and long-term treatment groups. It increased the level of locomotor activity and anxiety-like behavior, as evidenced by the increase in the number of movements and incidences of rearing and grooming in the caffeine-treated groups. No significant differences were observed between the groups in the Y-maze test. However, in the passive avoidance test, the escape latency in the caffeine-treated group was decreased significantly, indicating impaired memory acquisition. CONCLUSION: These results indicate that high-dose caffeine in adolescents may increase locomotor activity and anxiety-like behavior and impair learning and memory, irrespective of the duration of administration. The findings will be valuable for both evidence-based education and clinical practice.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Anxiety
/
United Nations
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Caffeine
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Incidence
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Cognition
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Models, Animal
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Education
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Energy Drinks
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Behavior Rating Scale
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Grooming
Type of study:
Incidence_studies
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Prognostic_studies
Limits:
Animals
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Humans
Language:
En
Journal:
Journal of Korean Biological Nursing Science
Year:
2019
Type:
Article