Effect of PTEN Polymorphism on the Development of Hepatitis B Virus-associated Hepatocellular Carcinoma
Journal of Liver Cancer
; : 46-54, 2019.
Article
in En
| WPRIM
| ID: wpr-765705
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: Phosphatase and tensin homolog (PTEN) is a known tumor suppressor gene that is downregulated in hepatocellular carcinoma (HCC). Here, we investigated the association between single nucleotide polymorphisms (SNPs) of PTEN and HCC development in patients with hepatitis B virus (HBV) infection. METHODS: Six SNPs of PTEN at positions rs1234221, rs1903860, rs1234220, rs1903858, rs2299941, and rs17431184 were analyzed in a development population (417 chronic HBV carriers without HCC and 281 chronic HBV carriers with HCC). PTEN rs1903858, rs1903860, and rs2299941 SNPs were further assessed for the development of HCC in a validation population of 200 patients with HBV-related liver cirrhosis. RESULTS: In the development population, PTEN rs1903860 C allele, rs1903858 G allele, and rs2299941 G allele were associated with a low risk of HCC. The haplotype A-T-A-A-A was associated with an increased risk of HCC (recessive model; odds ratio=2.277, 95% confidence interval [CI] =1.144-4.532, P=0.019). In the validation population, PTEN rs2299941 G allele was the only significant protective genetic polymorphism related to HCC development after adjustment for age and sex (hazard ratio=0.582, 95% CI =0.353–0.962, P=0.035). CONCLUSIONS: These findings suggest that genetic polymorphisms in PTEN may affect HCC development in patients with chronic HBV infection.
Key words
Full text:
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Index:
WPRIM
Main subject:
Polymorphism, Genetic
/
Haplotypes
/
Hepatitis B virus
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Genes, Tumor Suppressor
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Carcinoma, Hepatocellular
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Polymorphism, Single Nucleotide
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Alleles
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Hepatitis
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Hepatitis B
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Liver Cirrhosis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Journal of Liver Cancer
Year:
2019
Type:
Article