Hematologic Markers as a Predictive Factor for Moderate to Severe Obstructive Sleep Apnea Syndrome in Children and Adolescents
Journal of Sleep Medicine
;
: 20-26, 2018.
Article
in Korean
| WPRIM
| ID: wpr-766220
ABSTRACT
OBJECTIVES:
We conducted this study to evaluate the diagnostic value of hematologic markers for moderate to severe obstructive sleep apnea syndrome (OSAS).METHODS:
We performed the study using medical records from our sleep disorders center. We collected information regarding obstructive apnea-hypopnea index (oAHI), age, sex, body mass index, and complete blood counts with differential counts [white blood cell (WBC) count, neutrophil count, lymphocyte count, red blood cell distribution width (RDW), mean platelet volume, platelet count, platelet distribution width (PDW), neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio]. We excluded patients who were younger than 2 years, older than 14 years, obese/underweight, and those who had a hematologic or severe medical illness.RESULTS:
We assessed records from 57 patients (7.98±3.25 years old, 35 men). We classified the subjects into three groups based on their oAHI scores, as follows normal (oAHI < 1), mild OSAS (1≤oAHI < 5), and moderate/severe OSAS (oAHI≥5). Using a multivariate multinomial logistic regression model (pseudo R²=0.33), we found significant differences among the groups in RDW [moderate/severe OSAS vs. mild OSAS, adjusted odds ratio (OR) 8.77, p-value 0.03], PDW (mild OSAS vs. normal, adjusted OR 1.05, p-value 0.04), and WBC (moderate/severe OSAS vs. normal, adjusted OR 1.42, p-value 0.03).CONCLUSIONS:
RDW, PDW, and WBC had diagnostic value for moderate/severe OSAS in our study. Further prospective and validation studies are required to develop a screening tool for moderate/severe OSAS in children and adolescents.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Sleep Apnea Syndromes
/
Sleep Wake Disorders
/
Blood Cell Count
/
Blood Cells
/
Blood Platelets
/
Body Mass Index
/
Logistic Models
/
Odds Ratio
/
Mass Screening
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adolescent
/
Child
/
Humans
Language:
Korean
Journal:
Journal of Sleep Medicine
Year:
2018
Type:
Article
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