Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
Experimental & Molecular Medicine
; : 92-97, 2008.
Article
in En
| WPRIM
| ID: wpr-77110
Responsible library:
WPRO
ABSTRACT
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron chi neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCalpha translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCalpha-ERK1/2 pathway.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Phosphoproteins
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Pyrrolidinones
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Immunoblotting
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Cell Line
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Cell Survival
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Calcium
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Apoptosis
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Neuroprotective Agents
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Endothelin-1
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Endothelin-2
Limits:
Animals
Language:
En
Journal:
Experimental & Molecular Medicine
Year:
2008
Type:
Article