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Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 4-8, 2018.
Article in Chinese | WPRIM | ID: wpr-773305
ABSTRACT
OBJECTIVE@#This study aims to investigate the association between human leucocyte antigen (HLA)-DQB1 allele polymorphisms and the presence dental caries among the Uygur and Han children in Xinjiang.@*METHODS@#HLA-DQB1 allele in the Uygur and Han children with dental caries and healthy control in Xinjiang was tested (n=40) using the polymerase chain reaction-sequence specific primer (PCR-SSP) DNA parting technology.@*RESULTS@#A total of five specific loci were detected in the HLA-DQB1 locus among the Uygur and Han children. The frequency of the HLA-DQB1*02 allele in the Han group with severe caries (12.5%) was significantly lower than in the control group (32.5%) (P<0.05, OR=0.297). Moreover, the frequency of the HLA-DQB1*05 allele in the Uygur group with severe caries (37.5%) was significantly higher than in the control group (17.5%) (P<0.05, OR=2.829).@*CONCLUSIONS@#Caries susceptibility among the Uygur and Han children in Xinjiang is related to the HLA-DQB1 allele. The HLA-DQB1*02 allele may protect against caries among the Han children, whereas the HLA-DQB1*05 allele may be responsible for the susceptibility of the Uygur children to caries.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / China / Polymerase Chain Reaction / Genetic Predisposition to Disease / Dental Caries / Asian People / Alleles / Ethnology / HLA-DQ beta-Chains / Gene Frequency Limits: Child / Humans Country/Region as subject: Asia Language: Chinese Journal: West China Journal of Stomatology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / China / Polymerase Chain Reaction / Genetic Predisposition to Disease / Dental Caries / Asian People / Alleles / Ethnology / HLA-DQ beta-Chains / Gene Frequency Limits: Child / Humans Country/Region as subject: Asia Language: Chinese Journal: West China Journal of Stomatology Year: 2018 Type: Article