Research Progress of C-Myc in Chronic Myelogenous Leukemia --Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 297-300, 2019.
Article
in Zh
| WPRIM
| ID: wpr-774319
Responsible library:
WPRO
ABSTRACT
As a potential target for cancer treatment, the C-Myc high expresses abnormally in a variety of solid tumors and hematological malignancies in humans. In hematologic malignancies, the increasing expression of C-Myc is associated with poor prognosis of patients diffuse large B-cell lymphoma. However, some studies have shown that high expression of C-Myc might be one of the mechanisms of disease progression and abrupt change, therefore, it can promote the transformation of chronic myeloid leukemia. Besides, the high expression of C-Myc may lead to the decrease of the sensitivity of chronic myelogenous leukemia cells to imatinib. Therefore, C-Myc has been concerned in the study of imatinib drug resistance. This review will focuses on the latest research progress on the mechanism of C-Myc in chronic myeloid leukemia in recent years.
Full text:
1
Index:
WPRIM
Main subject:
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Proto-Oncogene Proteins c-myc
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Lymphoma, Large B-Cell, Diffuse
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Imatinib Mesylate
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2019
Type:
Article