The roles of habenula and related neural circuits in neuropsychiatric diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 310-317, 2019.
Article
in Zh
| WPRIM
| ID: wpr-775218
Responsible library:
WPRO
ABSTRACT
The habenula is a small and bilateral nucleus above dorsal thalamus, which contains several different types of neurons. The habenula has extensive connections with the forebrain, septum and monoaminergic nuclei in the midbrain and brainstem. Habenula is known as an 'anti-reward' nucleus, which can be activated by aversive stimulus and negative reward prediction errors. Accumulating researchs have implicated that the habenula is involved in several behaviors crucial to survival. Meanwhile, the roles of the habenula in neuropsychiatric diseases have received increasing attention. This review summaries the studies regarding the roles of habenula and the related circuits in neuropathic pain, depression, drug addiction and schizophrenia, and discusses the possibility to use the habenula as a treatment target.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Reward
/
Mesencephalon
/
Habenula
/
Depressive Disorder
/
Mental Disorders
/
Metabolism
/
Neurons
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2019
Type:
Article