Research advances on the role of exosomes in chemotherapy resistance of ovarian cancer / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 116-120, 2019.
Article
in Zh
| WPRIM
| ID: wpr-775246
Responsible library:
WPRO
ABSTRACT
Chemotherapy resistance is one of the biggest challenges in treatment of ovarian cancer. Mounting evidence shows that the exosomes shedding from tumor cells are considered to be involved in chemotherapy resistance of ovarian cancer by enhanced exosomal export of drugs, transferring RNAs or proteins and interfering with the bioactivity of therapeutic anti-tumor antibodies. In this review, we display the correlation between exosomes and chemotherapy resistance of ovarian cancer, the mechanism of exosomes involved in chemotherapy resistance of ovarian cancer, and discuss the potential clinical values of exosomes in chemotherapy resistance of ovarian cancer.
Full text:
1
Index:
WPRIM
Main subject:
Ovarian Neoplasms
/
Drug Resistance, Neoplasm
/
Therapeutic Uses
/
Drug Therapy
/
Exosomes
/
Carcinoma, Ovarian Epithelial
/
Metabolism
/
Antineoplastic Agents
Limits:
Female
/
Humans
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2019
Type:
Article