Expression of gene and its prognostic value in patients with acute myeloid leukemia / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 50-57, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-775254
ABSTRACT
OBJECTIVE@#To investigate the expression of Wilms'tumor 1 () gene in patients with acute myeloid leukemia (AML), and to explore its application in predicting prognosis of AML in patients with wild or mutated nucleophosmin 1() and Fms-like tyrosine kinase 3-internal tandem duplication ().@*METHODS@#One hundred and sixty-seven newly diagnosed AML patients(exclued M3 type) were enrolled in this study. The survival of patients were analyzed with Kaplan-Meier method. The clinical data, laboratory findings and the survival of patients were analyzed and compared between patients with high expression (high- group) and those with low expression (low- group), as well as among the patients with or wild type and mutants.@*RESULTS@#The overall response rates (ORR) in high- and low- groups were 65.9% (83/126) and 95.1% (39/41), respectively (0.05). In patients with wild type, the high- group had inferior ORR and 2-y OS rate (all 0.05).@*CONCLUSIONS@# gene overexpression indicated poor prognosis of AML patients; the patients with decreased gene expression ≥ 1 log after the first induction therapy show better prognosis than those with<1 log. The gene expression level at diagnosis can be used as an unfavorable prognostic factor for AML patients with or wild types.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Nuclear Proteins
/
Leukemia, Myeloid, Acute
/
Mortality
/
Disease-Free Survival
/
Gene Expression Profiling
/
WT1 Proteins
/
Diagnosis
/
Fms-Like Tyrosine Kinase 3
/
Kaplan-Meier Estimate
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2019
Type:
Article
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