Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 700-708, 2018.
Article
in English
| WPRIM
| ID: wpr-775501
ABSTRACT
In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of frequency-deviant stimulus (standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity (MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery Scale-Revised (CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions (small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location (frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Auditory Perception
/
Acoustic Stimulation
/
Severity of Illness Index
/
Brain Injuries
/
Consciousness Disorders
/
Electroencephalography
/
Evoked Potentials
/
Wavelet Analysis
/
Neuropsychological Tests
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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