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Expression and clinical significance of long non-coding RNA LINC00520 in laryngeal squamous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Article in Zh | WPRIM | ID: wpr-775946
Responsible library: WPRO
ABSTRACT
To investigate the expression of LINC00520 in laryngeal squamous cell carcinoma(LSCC),and analyze its relevance and roles in carcinogenesis and development of LSCC.The expression of LINC00520 in laryngeal squamous cell carcinoma tissue and paired adjacent normal tissue was determined by real-time PCR.The relationship between the expression of LINC00520 and the clinicopathological characteristics including clinical stage,pathological type,histological grade and lymph node metastasis of LSCC was analyzed.(1)The LINC00520 expression level was significantly upregulated in LSCC tissues compared to that of paired adjacent normal tissues(0.05).The LINC00520 expression level had no significant changes in poorly differentiated LSCC compared with that of well and moderately differentiated counterparts(>0.05).Moreover,the expression of LINC00520 had no significant difference between T1+T2 stage and T3+T4 stage LSCC tissues(>0.05).Interestingly,the LINC00520 level in LSCC with lymph node metastasis was significantly higher than that in patients without lymph node metastasis(<0.01).Upregulation of LINC00520 in LSCC may contribute to its metastasis.
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Full text: 1 Index: WPRIM Main subject: Pathology / Prognosis / Carcinoma, Squamous Cell / Up-Regulation / Laryngeal Neoplasms / RNA, Long Noncoding / Lymphatic Metastasis / Metabolism Type of study: Prognostic_studies Limits: Humans Language: Zh Journal: Lin chuang er bi yan hou ke za zhi Year: 2018 Type: Article
Full text: 1 Index: WPRIM Main subject: Pathology / Prognosis / Carcinoma, Squamous Cell / Up-Regulation / Laryngeal Neoplasms / RNA, Long Noncoding / Lymphatic Metastasis / Metabolism Type of study: Prognostic_studies Limits: Humans Language: Zh Journal: Lin chuang er bi yan hou ke za zhi Year: 2018 Type: Article