Research Advances in Mitogen-activated Protein Kinases in Central and Peripheral Sensitization of Diabetic Neuropathic Pain / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 118-123, 2019.
Article
in Zh
| WPRIM
| ID: wpr-776063
Responsible library:
WPRO
ABSTRACT
Mitogen-activated protein kinases(MAPKs)are Ser/Thr kinases consisting of extracellular regulated protein kinases(ERK)1/2,c-Jun N-terminal kinase 1/2/3,p38 isoforms(α,β,γ,and δ),and ERK5,which mediate a range of cellular activities including proliferation,differentiation,apoptosis,immunity,and inflammation. Pain sensitization is a remodeling mechanism of central and peripheral nociceptor. A growing number of evidences have indicated that MAPKs are extensively activated in the spinal dorsal cord and dorsal root ganglions in the animal models of diabetic neuropathic pain(DNP)and play an important role in the central and peripheral sensitization of DNP. In addition,some drugs can alleviate DNP by suppressing MAPKs activation of central and peripheral nervous system. This article summarizes the research progress of MAPKs in central and peripheral sensitization of DNP.
Full text:
1
Index:
WPRIM
Main subject:
Mitogen-Activated Protein Kinases
/
P38 Mitogen-Activated Protein Kinases
/
Diabetic Neuropathies
/
Ganglia, Spinal
/
Neuralgia
Limits:
Animals
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2019
Type:
Article